Air Europa (UX, Palma Son Sant Joan) will run a 2x weekly service between Madrid Barajas and San Pedro Sula in Honduras over the period covering April 26 to October 26, 2017. The route, operated using A330-200 aircraft, will become the Honduran industrial hub's first intercontinental service once it is launched.

Other commercial operators to serve San Pedro Sula include: Aerolineas Sosa; AeroMéxico; American Airlines; Amerijet International (Cargo); Avianca (through its various subsidiaries Isleña Airlines, TACA International Airlines, Trans American Airlines, and Aviateca Guatemala), CM Airlines, Copa Airlines, Delta Air Lines, DHL Aero Expreso (Cargo), Spirit Airlines, TAG Airlines, Tropic Air, and United Airlines.