Air Europa (UX, Palma Son Sant Joan) will run a 2x weekly service between Madrid Barajas and San Pedro Sula in Honduras over the period covering April 26 to October 26, 2017. The route, operated using A330-200 aircraft, will become the Honduran industrial hub's first intercontinental service once it is launched.

Other commercial operators to serve San Pedro Sula include: Aerolineas Sosa; AeroMéxico; American Airlines; Amerijet International (Cargo); Avianca (through its various subsidiaries Isleña Airlines, TACA International Airlines, Trans American Airlines, and Aviateca Guatemala), CM Airlines, Copa Airlines, Delta Air Lines, DHL Aero Expreso (Cargo), Spirit Airlines, TAG - Transportes Aéreos Guatemaltecos, Tropic Air, and United Airlines.