Serene Air (ER, Islamabad International) will initially serve the domestic Pakistani market before venturing abroad. A Radixx International press release confirming Serene Air's choice of IT systems said the start-up would serve Lahore International, Islamabad International, Karachi International, Faisalabad, Quetta, Peshawar, and Skardu with approximately 125 weekly flights initially.

Serene Air will launch with a trio of B737-800s but additional aircraft will provide for its expansion both domestically and, eventually, internationally. Once it has completed its certification, expected during the first half of this year, Serene Air will compete with the likes of AirBlue (PA, Karachi International), PIA - Pakistan International Airlines (PK, Islamabad International), and Shaheen Air International (Karachi International).