Vueling Airlines (VY, Barcelona El Prat) will commence scheduled A321-200 (sl) operations on July 3, 2015 with the type's first revenue flight slated to be VY 2974 Barcelona El Prat-Nantes. Of the ten airframes the Spanish LCC has on order from Airbus (AIB, Toulouse Blagnac), only one - cn 6638 - has so far rolled off the production line.

The Spanish LCC plans to use the type on flights from its Barcelona Prat hub to destinations located through North Africa, the Mediterranean, continental Europe, the United Kingdom, Scandinavia, and Russia.