Airline4.0 (Las Vegas McCarran) is a Nevada-based start-up looking to become the United States' fourth largest carrier after American Airlines (AA, Dallas/Fort Worth), United Airlines (UA, Chicago O'Hare) and Delta Air Lines (DL, Atlanta Hartsfield Jackson). A self-styled "Next Generation" carrier, Airline 4.0 is currently in the seeding stage of the start-up process. In the coming months, Airline 4.0 will court prospective airports, equipment suppliers, and other industry-related services leading towards government certification for regularly-scheduled commercial flights according to statements made on its website.

Las Vegas McCarran is also home to two other start-ups: American West Jets (Las Vegas McCarran) and Avatar Airlines (Las Vegas McCarran).